Studies on the formulation optimization and controlled ionic gelation of chitosan nanoparticles using TPP-HP-beta-CD inclusion complex

Agardan M.

ISTANBUL JOURNAL OF PHARMACY, vol.50, no.1, pp.54-59, 2020 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.26650/istanbuljpharm.2019.0015
  • Journal Name: ISTANBUL JOURNAL OF PHARMACY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Page Numbers: pp.54-59
  • Keywords: Chitosan nanoparticles, controlled ionic gelation, cyclodextrins, POLYMERIC NANOPARTICLES
  • Gazi University Affiliated: Yes

Abstract

Background and Aims: Ionic gelation strategy is the most common method used for the preparation of chitosan nanoparticles to obtain controlled drug delivery. Although it is a convenient and easy method, it is highly related with particle aggregation, high polidispersity index and insufficient physical/chemical stability. The aim of this study was the development of chitosan nanoparticles using tripolyphosphate-hydroxy propyl beta-cyclodextrin or tripolyphosphate-sulfobutyl ether beta-cyclodextrin inclusion complex as an alternative to TPP, and hence to increase physical stability, reduce polidispersity index and develop a stable nanocarrier for drug delivery purposes.