Effects of chitosan and platelet-rich plasma on facial nerve regeneration in an animal model

---

Copy For Citation

Şahin M. M., Cayonu M., Dinc S. K., Ozkocer E., Ilhan M., Uzunoğlu E., ...More

EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, vol.279, no.2, pp.987-994, 2022 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 279 Issue: 2
• Publication Date: 2022
• Doi Number: 10.1007/s00405-021-06859-6
• Journal Name: EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
• Page Numbers: pp.987-994
• Keywords: Chitosan, Platelet-rich plasma, Facial nerve, Regeneration, Rat model, MESENCHYMAL STEM-CELLS, GROWTH-FACTOR PDGF, QUALITY-OF-LIFE, SCIATIC-NERVE, METHYLPREDNISOLONE, PARALYSIS, INJURY, EXPRESSION, SYSTEM, REPAIR
• Gazi University Affiliated: Yes

Abstract

Purpose There is still no widely-accepted local agent proven to be effective in nerve regeneration. We aimed to investigate the effects of chitosan gel and platelet-rich plasma Materials and methods Electrophysiological measurements were performed before and immediately after injury. The injured nerves were covered with spongostan impregnated with the following agents: Group 1 (Control Group): Saline at a dose of 50 mu l; Group 2: Chitosan (CHT) at a dose of 50 mu l; Group 3: PRP at a dose of 50 ml; and Group 4: a solution of CHT with PRP (1:1). The final measurements were performed after 3 weeks and the injured nerve of each rat was removed. Results There were statistically-significant differences between the groups regarding the measurements of the after-treatment values of stimulus threshold (p < 0.05). The best improvement in electrophysiological measurement and histopathological evaluation was found in Group 4 (CHT-PRP). Conclusion Chitosan gel has a positive effect on nerve healing and applying it along with PRP can enhance the effect of chitosan.