Interobserver Variability in Ultrasound-Based Liver Fat Quantification


ŞENDUR H. N. , CERİT M. N. , IBRAHIMKHANLI N., Sendur A. B. , ÖZHAN OKTAR S.

JOURNAL OF ULTRASOUND IN MEDICINE, 2022 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2022
  • Doi Number: 10.1002/jum.16048
  • Journal Name: JOURNAL OF ULTRASOUND IN MEDICINE
  • Journal Indexes: Science Citation Index Expanded, Scopus, Biotechnology Research Abstracts, CAB Abstracts, CINAHL, Compendex, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: hepatosteatosis, fatty liver, interobserver variability, quantitative ultrasound, tissue attenuation imaging, tissue scatter distribution imaging, AMERICAN ASSOCIATION, HEPATIC STEATOSIS, DIAGNOSIS, VALIDATION, MANAGEMENT

Abstract

Objectives To assess interobserver variability in ultrasound-based quantitative liver fat content measurements and to determine how much time these quantitative ultrasound (QUS) techniques require. Methods One hundred patients with known or suspected of having nonalcoholic fatty liver disease were included in this prospective study. Two observers who were blinded to each other measurements performed tissue attenuation imaging (TAI) and tissue scatter distribution imaging (TSI) techniques independently. Both observers assessed hepatic steatosis visually and obtained 5 measurements for each QUS technique and the median values of the measurements were recorded. Spearman's correlation test was used to assess the correlation between QUS measurements and visual hepatic stetaosis grades. Intraclass correlation coefficient (ICC) test was used to assess interobserver variability in QUS measurements. Results The median values of TAI measurements for the observers 1 and 2 were 0.75 and 0.74 dB/cm/MHz, respectively. The median values of TSI measurements for the observers 1 and 2 were 93.53 and 92.58, respectively. The interobserver agreement in TAI (ICC: 0.970) and TSI (ICC: 0.938) measurements were excellent. The mean of the required time period for TAI technique were 55.1 +/- 7.8 and 59.9 +/- 6.6 seconds for the observers 1 and 2, respectively. The mean of the required time period for TSI technique were 49.1 +/- 5.8 and 54.1 +/- 5.4 seconds for the observers 1 and 2, respectively. Conclusion The current study revealed that both TAI and TSI techniques are highly reproducible and can be implemented into daily practice with little additional time requirement.