Determination of serum carbohydrate-deficient transferrin levels in patients with alcohol use disorders, cirrhosis, systemic lupus erythematosis Alkol kullanim bozukluǧu, siroz, sistemik lupus eritematozus'lu hastalarda serum carbohydrate-deficient transferrin seviyelerinin belirlenmesi

Öztürk Y., Öztürk G. T., ŞAKRAK Ö., Işik E., Erdal H., PAŞAOĞLU H.

Gazi Medical Journal, cilt.22, sa.4, ss.110-112, 2011 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 4
  • Basım Tarihi: 2011
  • Doi Numarası: 10.5152/gmj.2011.24
  • Dergi Adı: Gazi Medical Journal
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.110-112
  • Anahtar Kelimeler: CDT, alcohol dependence, cirrhosis, SLE
  • Gazi Üniversitesi Adresli: Evet

Özet

Objective: Carbohydrate-deficient transferrin (CDT) is a glycoprotein that contains sialic acid and is formed by reduction of carbohydrates in transferrin structure. In this study we planned to measure levels of CDT in patients with alcohol use disorders, cirrhosis, systemic lupus erythematosis (SLE). In this way, by looking at the first period, we aimed to show the utility of CDT in these diseases as a marker for early diagnosis. Methods: Twenty-nine patients with alcohol use disorders, 13 patients with cirrhosis, 17 patients with SLE and 31 healthy volunteers were included in the study. Serum CDT levels were measured by high performance liquid chromatography (HPLC) in all patients and healthy volunteers, and the means of the four groups were compared. Results: CDT levels in patients with alcohol use disorders, cirrhosis and SLE were determined as significantly high compared to the control group (p 1<0.001, p 2=0.027, p 3=0.001). Conclusion: The CDT level are useful as a diagnostic marker in patients with suspected alcohol use disorders, cirrhosis and SLE. ©Copyright 2011 by Gazi University Medical Faculty.