Topical application of olive oil macerate of Momordica charantia L. promotes healing of excisional and incisional wounds in rat buccal mucosa

İlhan M., Bolat I. E., SÜNTAR İ., Koklu H. K., Cankal D. A., KELEŞ H., ...Daha Fazla

Archives of Oral Biology, cilt.60, sa.12, ss.1708-1713, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 60 Sayı: 12
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.archoralbio.2015.09.006
  • Dergi Adı: Archives of Oral Biology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1708-1713
  • Anahtar Kelimeler: Anti-inflammatory, Cucurbitaceae, Excision, Incision, Momordica charantia, Tensiometer, Wound healing, BITTER GOURD, EXTRACT, ANTIOXIDANT, MICE
  • Gazi Üniversitesi Adresli: Evet

Özet

© 2015 Elsevier Ltd. All rights reserved.Objective In Turkish folk medicine Momordica charantia L. is used for wound healing. The aim of the present study is to investigate this folkloric knowledge and confirm the plant's potential effect on buccal mucosa wound in the rat. Design Wound healing activity of olive oil macerate of Momordica charantia L. was investigated in linear incision and circular excision wound models created in the buccal mucosa of the rat. The tissues were histopathologically evaluated, moreover, hydroxyproline contents of the tissues were determined. The anti-inflammatory activity was also assessed by using Whittle method with some modifications. Results Olive oil macerate of M. charantia showed significant wound healing activity both in incision (45.1%) and excision (89.8%) wound models and demonstrated anti-inflammatory activity with the inhibition value of 31.3% at the dose of 100 mg/kg. Conclusion The experimental data revealed that M. charantia showed significant wound healing and anti-inflammatory effect.