Akademik Veri Yönetim Sistemi
Turk Onkoloji Dergisi, cilt.40, sa.1, ss.20-29, 2025 (ESCI)
OBJECTIVE Maspin is a member of the serpin family that targets proteinases and exhibits characteristics of a tumor suppressor protein. The aim of our study is to evaluate the impact of maspin expression on survival rates in patients diagnosed with locally advanced rectal cancer. METHODS A retrospective analysis was conducted on a dataset of 60 patients who had received a histopathological diagnosis of rectal cancer. Maspin expression was assessed using the Ventana Benchmark XT device with automatic immunohistochemical staining via the streptavidin-biotin immunoperoxidase technique. A survival analysis was performed by examining maspin in the specimens of these patients. RESULTS In terms of maspin staining, 37 patients (61.7%) were negative, while 23 patients (38.3%) were positive (18 cytoplasmic, 2 nuclear, and 3 both). The 3-year overall survival (OS) was 91.3% in maspin-positive patients and 73% in maspin-negative patients. Clinical T stage was significantly related to OS (p=0.028). Multivariate analysis showed nuclear maspin staining was significantly associated with DFS (p=0.004), and T stage was a significant factor for OS, independent of nuclear maspin expression (p=0.011). CONCLUSION Our study underscores the strong link between nuclear maspin staining and disease-free survival in rectal cancer patients, highlighting its promising potential as a prognostic biomarker for future research.