MEDICAL JOURNAL OF BAKIRKOY, cilt.11, sa.3, ss.95-98, 2015 (ESCI)
Objective: Adiponectin from adipocytokines plays role in neuro-inflammation, neuroimmunoendocrine system modulation and immune system regulation and has anti-inflammatory and protective effects. It functions by interacting pro-inflammatory cytokines, vasoactive peptides and complement proteins through peripheral and central mechanisms. The studies related to immunopathogenesis of Multiple Sclerosis (MS) progressing with neuroinflammation and neurodegeneration are focused on immune cells, cytokine, chemokines, membrane proteins, adhesion molecules and gene polymorphisms. We planned to determine the role of adipocyte related adiponectin in MS immunopathogenesis since the immunological functions of adipose tissue has drawn attention in the last years.