Changes in oxidative stress and cellular immunity serum markers in attention-deficit/hyperactivity disorder

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Ceylan M. F., Sener S., Bayraktar A. C., KAVUTÇU M.

PSYCHIATRY AND CLINICAL NEUROSCIENCES, cilt.66, sa.3, ss.220-226, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 66 Sayı: 3
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1111/j.1440-1819.2012.02330.x
  • Dergi Adı: PSYCHIATRY AND CLINICAL NEUROSCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.220-226
  • Anahtar Kelimeler: attention-deficit/hyperactivity disorder, cellular immunity, oxidative stress, DEFICIT HYPERACTIVITY DISORDER, ANTIOXIDANT DEFENSE SYSTEM, SCHOOL-AGE-CHILDREN, NITRIC-OXIDE, XANTHINE-OXIDASE, ADENOSINE-DEAMINASE, BIPOLAR DISORDER, NEUROPSYCHIATRIC DISORDERS, ANTIDEPRESSANT TREATMENT, SUPEROXIDE-DISMUTASE
  • Gazi Üniversitesi Adresli: Evet

Özet

Aims: Attention-deficit/hyperactivity disorder (ADHD) is a developmental disorder with an etiopathogeny not fully understood. According to the prevailing view, the main factors contributing to the disorder are prefrontal dopamine deficiency and central dopaminergic dysfunction, but the factors/mechanisms involved in the brain dysfunction and its consequences are not well known. We suggest that changes in oxidative metabolism and cellular immunity may be involved. In this study, we aimed to investigate whether there are associations between ADHD and changes in serum levels of nitric oxide synthase (NOS), xanthine oxidase (XO), glutathione S-transferase (GST) and paraoxonase-1 (PON-1) activities, which are important markers of oxidative stress, and adenosine deaminase (ADA) activity, marker of cellular immunity.