Bendiocarb-induced nephrotoxicity in rats and the protective role of vitamins C and E

Adiguzel Ç., KALENDER Y.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, vol.27, no.6, pp.6449-6458, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 27 Issue: 6
  • Publication Date: 2020
  • Doi Number: 10.1007/s11356-019-07260-x
  • Journal Name: ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, IBZ Online, ABI/INFORM, Aerospace Database, Agricultural & Environmental Science Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, EMBASE, Environment Index, Geobase, MEDLINE, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
  • Page Numbers: pp.6449-6458
  • Keywords: Bendiocarb, Nephrotoxicity, Oxidative damage, Histopathology, Electron microscopy, Antioxidants, INDUCED OXIDATIVE STRESS, CARBAMATE INSECTICIDES, PESTICIDES, ORGANOPHOSPHORUS, QUERCETIN, LIVER, ATTENUATION, CARBOFURAN, TOXICITY, TISSUES
  • Gazi University Affiliated: Yes

Abstract

Bendiocarb is a pesticide carbamate which is used to protect agricultural products and animals. In this study, rats were given orally with bendiocarb and also other chemicals via gavage. Male rats were randomly divided into eight groups (n = 6): group 1 served as controls; group 2 received vitamin C (100 mg/kg bw); group 3 received vitamin E (100 mg/kg bw); group 4 received vitamins C plus E; group 5 received bendiocarb (0.8 mg/kg 1/50 LD50); group 6 received both bendiocarb and vitamin C; group 7 received both bendiocarb and vitamin E; and group 8 received both bendiocarb and vitamin C and E via oral gavage. Degenerative changes and biochemical differences in rat kidney were investigated after 4 weeks of especially bendiocarb treatment. While biochemical values were normal in the control group, it was observed that CAT, SOD, GPx, and GST values decreased, while MDA, creatine, urea, and uric acid values increased in the pesticide-treated groups. It was also reported that bendiocarb caused cytopathological and histopathological changes in rat kidney. We have shown that the application of vitamins has a therapeutic effect on the evaluated parameters.