THE RELEASE OF NAPROXEN IN FATTY SUPPOSITORY BASES BY BETA-CYCLODEXRIN COMPLEXATION

CELEBI N., ISCANOGLU M., DEGIM T.

PHARMAZIE, cilt.46, sa.12, ss.863-865, 1991 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 12
  • Basım Tarihi: 1991
  • Dergi Adı: PHARMAZIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.863-865
  • Gazi Üniversitesi Adresli: Hayır

Özet

The effect of beta-cyclodextrin (beta-CD) on the release of naproxen (1) from fatty suppository bases was investigated. The solid complexes of 1 with beta-CD in a molar ratio of 1:1 were prepared by using the kneading, co-precipitation and grinding method. Witepsol(R) H15 and Massa Estarinum B suppositories were prepared, containing the intact 1 and 1-beta-CD complex, respectively. The in vitro release of 1 from fatty bases was examined. The release data were assessed kinetically. The best fit was obtained with Q vs. the square root of time.