Effect of a Chloride Channel Inhibitor, 5-Nitro-2-(3-Phenylpropylamino)-Benzoate, on Endothelin-1 Induced Vasoconstriction in Rabbit Basilar Artery

Dogulu, Fikret; Barun, SÜREYYA; Emmez, ÖMER; Elmas, ÇİĞDEM; Onal, AHMET; Belen, HAYRUNNİSA; Erdogan, Deniz; Ilgit, ERHAN; Saridglu, Yusuf; Kurt, GÖKHAN; Ercan, Sevim; Baykaner, M.

Effect of a Chloride Channel Inhibitor, 5-Nitro-2-(3-Phenylpropylamino)-Benzoate, on Endothelin-1 Induced Vasoconstriction in Rabbit Basilar Artery

Dogulu F., Barun S., Emmez H., Elmas Ç., Onal B., Belen H. B., ...Daha Fazla

TURKISH NEUROSURGERY, cilt.19, sa.4, ss.380-386, 2009 (SCI-Expanded, Scopus, TRDizin)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 19 Sayı: 4
Basım Tarihi: 2009
Dergi Adı: TURKISH NEUROSURGERY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.380-386
Anahtar Kelimeler: 5-nitro-2-(3-phenylpropylamino)-benzoate, Cl channel, Endothelin-1, Cerebral vasospasm, CEREBRAL VASOSPASM, SUBARACHNOID HEMORRHAGE, ACTIVATED CHLORIDE, POTASSIUM CURRENTS, NIFLUMIC ACID, CL, TONE, DEPOLARIZATION, NEUROTOXICITY, NORADRENALINE
Gazi Üniversitesi Adresli: Evet

Özet

AIM: Endothelin-1 (ET-1) has been implicated in the pathophysiology of cerebral vasospasm. Chloride (Cl-) channels exist in vascular smooth muscle and activation of these channels leads to depolarization and contraction. The aim of the present study was to test the effect of 5-nitro-2-(3-phenylpropylamino)-benzoate (NPPB), a Cl- channel antagonist, on the ET-1-induced cerebral vasospasm in rabbit basilar artery and thus investigate the contribution of Cl- channels.