Germ cell tumor showing partial trisomy 1 in a gonadectomized intersex child with monosomy X and double Y mosaicism

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Ogur G., PINARLI F. G., Dagdemir A., Artan S., Ariturk E., Elli M., ...Daha Fazla

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, cilt.28, sa.11, ss.750-754, 2006 (SCI-Expanded, Scopus)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 28 Sayı: 11
• Basım Tarihi: 2006
• Doi Numarası: 10.1097/01.mph.0000243651.33561.d4
• Dergi Adı: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.750-754
• Gazi Üniversitesi Adresli: Hayır

Özet

High incidence of germ cell tumors arising from dysgenetic gonads in patients with sexual chromosome abnormalities has been described, especially in patients with a Y chromosome bearing cell line. Here we report a 14-year-old patient with ambiguous genitalia. Constitutional karyotype showed 45,X/46,X,derY [?t(Yp;Yq)] mosaicism. The patient developed an abdominally located mixed malignant germ cell tumor 5 years after the removal of the dysgenetic gonads. Tumor karyotype showed partial trisomy 1q, a derivative 8q, and a hyperdiploidy with + X, + 7, + 12, + 15, + 19, + 21, and an unidentified marker.