Evaluation of intraprostatic metabolism of 1,25-dihydroxyvitamin D-3 (calcitriol) using a microdialysis technique

Konety B., Somogyi G., Atan A., Muindi J., Chancellor M., Getzenberg R.

UROLOGY, vol.59, no.6, pp.947-952, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 59 Issue: 6
  • Publication Date: 2002
  • Doi Number: 10.1016/s0090-4295(01)01652-1
  • Journal Name: UROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.947-952
  • Gazi University Affiliated: No

Abstract

Objectives. 1,25-dihydroxyvitamin D-3 (calcitriol) inhibits prostate cancer growth in vitro and in vivo. We used a prostate microdialysis technique to better understand the intraprostatic pharmacokinetics of calcitriol, which in turn would facilitate planning for systemic calcitriol therapy in patients with prostate cancer.