Differential pulse polarographic determination of moxifloxacin hydrochloride in pharmaceuticals and biological fluids

Inam R., Mercan H., Yilmaz E., Uslu B.

ANALYTICAL LETTERS, cilt.40, sa.3, ss.529-546, 2007 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 3
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1080/00032710600964817
  • Dergi Adı: ANALYTICAL LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.529-546
  • Anahtar Kelimeler: moxifloxacin, differential pulse polarography, pharmaceutics, serum, urine, PERFORMANCE LIQUID-CHROMATOGRAPHY, HUMAN PLASMA, VOLTAMMETRY, GATIFLOXACIN, LEVOFLOXACIN, ELECTRODES, FLEROXACIN, TABLETS, MEDIA, ACID
  • Gazi Üniversitesi Adresli: Evet

Özet

A simple, fast, sensitive and fully validated differential pulse polarographic ( DPP) method for the determination of trace amounts of moxifloxacin in pharmaceutics, serum and urine is reported. Moxifloxacin exhibited irreversible cathodic peak over the pH 5.00 - 11.00 in Britton - Robinson ( B - R) buffer. At pH 10.00 ( the analytical pH), a well-defined peak at -1.61 V versus saturated calomel electrode was obtained. The current has been characterized as being diffusion-controlled process. The diffusion current constant (i(d)) was 1.48 +/- 0.12 and the current - concentration plot was rectilinear over the range from 5 x 10(-7) to 1 x 10(-4) M with correlation coefficient (n = 10) of 0.995.