Choroidal Neovascular Membrane in Age-Related Macular Degeneration is Associated with Increased Interleukin-6

Yildirim Z., Ucgun N. I., Yildirim F., SEPİCİ DİNÇEL A.

INTERNATIONAL JOURNAL OF GERONTOLOGY, vol.6, no.2, pp.101-104, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 2
  • Publication Date: 2012
  • Doi Number: 10.1016/j.ijge.2012.01.018
  • Journal Name: INTERNATIONAL JOURNAL OF GERONTOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.101-104
  • Keywords: AMD, IL-6, IL-1 beta, inflammation, VEGF, ENDOTHELIAL GROWTH-FACTOR, NITRIC-OXIDE SYNTHASE, C-REACTIVE PROTEIN, COMPLEMENT ACTIVATION, EPITHELIAL-CELLS, DRUSEN, MACULOPATHY, EXPRESSION, ATHEROSCLEROSIS, PERMEABILITY
  • Gazi University Affiliated: No

Abstract

Background: Age-related macular degeneration (AMD) is the leading cause of irreversible visual impairment and blindness among persons aged 60 years and older. Although inflammation has been postulated to have a role in the pathogenesis of AMD, epidemiologic studies have not shown a relationship between systemic inflammation or presence of inflammatory markers at AMD. The aim of our study was to evaluate the differences in various types of cytokines and intracelluler signaling molecules for the onset and progression of AMD.