Behavioral and Neurodevelopmental Effects of Early Interventions in Adult Wistar Rats

Küçükkarapinar M., Dönmez A., Candansayar S., Bozkurt A., Akçay E., Gülbahar Ö., ...Daha Fazla

NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY, cilt.58, sa.2, ss.137-145, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.29399/npa.24943
  • Dergi Adı: NOROPSIKIYATRI ARSIVI-ARCHIVES OF NEUROPSYCHIATRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CINAHL, EMBASE, Psycinfo, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.137-145
  • Anahtar Kelimeler: Wistar rats, behavioral manipulations, NR2B NMDA receptor, aggression, MATERNAL SEPARATION, MEMORY FUNCTION, STRESS, HIPPOCAMPUS, EXPRESSION, ENRICHMENT, RESPONSES, BRAIN, EXPERIENCE, RECEPTORS
  • Gazi Üniversitesi Adresli: Evet

Özet

Introduction: Interventions performed in the early period of life are associated with cognitive and behavioral changes in adulthood. The effects of interventions such as exposure to an early stressful life event or environmental enrichment on cognitive and behavioral development are studied. The aim of this study is to develop a new intervention method, to investigate the effects of early interventions on social interaction, memory anxiety levels and NR2B levels in prefrontal and hippocampus in adulthood. The hypothesis of the study is that exposure to the ambivalent mother will affect the behavioral performance of rats at least as much as one hour apart from the mother in the adult period and cause changes in the prefrontal cortex and hippocampus in the NR2B levels.