Is there a role for nitric oxide activity in cervicogenic headache?

Inan N., YILMAZ G., Surer H., Coskun Z., Ucler S., Cavdar L., ...More

FUNCTIONAL NEUROLOGY, vol.22, no.3, pp.155-157, 2007 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 3
  • Publication Date: 2007
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.155-157


Cervicogenic headache (CEH) is a unilateral headache that can be provoked by neck movement, awkward head positions or pressure on tender points in the neck. The mechanisms underlying the stimulation of pain in CEH are not clearly known. In this study, we measured serum nitrate and nitrite levels as an index of nitric oxide (NO) activity in 15 patients with CEH during headache and headache-free periods and in 15 healthy controls. Total nitrate+nitrite levels were found to be higher in CEH patients during headache periods than in healthy controls (20.7 +/- 3.8 mu mol/l vs 14.4 +/- 3.6 mu mol/l, p < 0.001), but not in CEH patients during heaclache-free periods (16.1 +/- 2.2 mu mol/l) compared with the controls (p > 0.05).