Electrochemical Behavior and Ultrasensitive, Simple and Effective Voltammetric Determination of Acetaminophen Using Modified Glassy Carbon Electrode Based on 4-Hydroxyquinoline-3-Carboxylic Acid

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Uzun D., Tabanlıgil Calam T.

ELECTROANALYSIS, vol.35, no.4, pp.1-11, 2023 (SCI-Expanded)

  • Publication Type: Article / Article
  • Volume: 35 Issue: 4
  • Publication Date: 2023
  • Doi Number: 10.1002/elan.202200182
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Applied Science & Technology Source, BIOSIS, Chemical Abstracts Core, Chimica, Communication Abstracts, Metadex, Civil Engineering Abstracts
  • Page Numbers: pp.1-11
  • Gazi University Affiliated: Yes


An electrochemical oxidation of acetaminophen (ACOP) has been successfully performed by using glassy carbon electrode covered with 4-hydroxyquinoline-3-carboxylic acid (4HQ3CA) to reinforce electrode’s feature. To characterize the modified electrode (4HQ3CA/GC), electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and Fourier transform infrared spectroscopy (FT-IR) techniques were used. The finding optimum conditions (supporting electrolyte, pH) and the electrochemical determination studies were performed with differential pulse voltammetry (DPV). A wide concentration range from 0.0025 μM to 141 μM with a limit of detection (LOD) of 5.98×10-10 M (3s/m) was obtained. This prepared sensor was carried out for the determination of ACOP in pharmaceutical sample.