Renal safety and extrahepatic defluorination of sevoflurane in hepatic transplantations

Kanbak M., Karagoz A. H. , Erdem N., Oc B., Saricaoglu F., Ertas N. , ...More

TRANSPLANTATION PROCEEDINGS, vol.39, no.5, pp.1544-1548, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 5
  • Publication Date: 2007
  • Doi Number: 10.1016/j.transproceed.2007.01.081
  • Page Numbers: pp.1544-1548


Background. The main metabolic pathway for defluorination of sevoflurane in the liver produces inorganic fluoride (171). The metabolism and effect of sevoflurane on the kidney is not clear during anhepatic phase in liver transplantation. The goal of the present study was to investigate the metabolism and renal effect of sevoflurane by measuring plasma and urine inorganic fluoride, urinary N-acetyl-glucosaminidase (NAG), and plasma creatinine levels in patients undergoing liver transplantations.