The effects of gentamicin on the activities of glutathione peroxidase and superoxide dismutase enzymes and malondialdehyde levels in heart tissues of guinea pigs

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Ozturk H., Kavutcu M., Kacmaz M., Canbolat O., Durak I.

CURRENT MEDICAL RESEARCH AND OPINION, vol.14, no.1, pp.47-52, 1997 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 14 Issue: 1
• Publication Date: 1997
• Doi Number: 10.1185/03007999709113342
• Journal Name: CURRENT MEDICAL RESEARCH AND OPINION
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.47-52
• Gazi University Affiliated: Yes

Abstract

In this study, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities and malondialdehyde (MDA) levels were measured in heart tissues from guinea pigs treated with gentamicin and gentamicin plus vitamin E combination. Mean values were compared with those of the controls treated with only physiological saline solution. The activities of SOD and GSH-Px were found to be lower and the MDA level higher in the hearts from gentamicin-treated animals compared with those of the controls. In the gentamicin plus vitamin E group, however, tissue SOD activity was found to be increased and MDA level decreased significantly relative to the gentamicin group. GSH-Px activity was lowest in this group.