SERUM BETA-CAROTENE, VITAMIN-E, VITAMIN-C AND MALONDIALDEHYDE LEVELS IN SEVERAL TYPES OF CANCER
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, vol.20, no.5, pp.259-263, 1995 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 20 Issue: 5
- Publication Date: 1995
- Doi Number: 10.1111/j.1365-2710.1995.tb00660.x
- Journal Name: JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.259-263
- Gazi University Affiliated: Yes
Abstract
We measured the levels of serum carotenoids (beta-carotene), total tocopherol (vitamin E), ascorbic acid and malondialdehyde (MDA) in newly diagnosed cancer cases. Levels of the antioxidants and MDA in serum samples from 208 subjects with cancer affecting different sites (59 breast, 38 head and neck, 46 genitourinary, 12 lung, 20 gastrointestinal and 33 other sites) were compared with levels in 156 controls. Cases and controls were compared with respect to a number of potentially confounding factors: age, sex, smoking status, Quetelet index (kg/m(2)), diet and alcohol intake. Mean (+/- SD) levels of beta-carotene, vitamin E and vitamin C were significantly lower among the cases than the controls (49.35 +/- 36.55 mu g/l, 0.60 +/- 0.14 mg/dl, 0.40 +/- 0.27 mg/dl and 75.31 +/- 28.59 mg/dl, 0.98 +/- 0.13 mg/dl, 0.88 +/- 0.47 mg/dl, respectively) (P<0.05).