Spectroscopic studies on the interactions of 5-ethyl-6-phenyl-3,8-bis((3-aminoalkyl)propanamido)phenanthridin-5-ium derivatives with G-quadruplex DNA

Yalcin E., Duyar H., Ihmels H., Seferoglu Z.

Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, vol.196, pp.432-438, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 196
  • Publication Date: 2018
  • Doi Number: 10.1016/j.saa.2018.02.051
  • Journal Name: Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.432-438
  • Keywords: Ethidium derivatives, Microwave-assisted synthesis, G-quadruplex DNA, Spectrophotometric method, Thermal DNA denaturation, CD, RAY FIBER DIFFRACTION, CIRCULAR-DICHROISM, ETHIDIUM-BROMIDE, G-QUARTETS, TELOMERASE, BINDING, ACID, RECOGNITION, NMR, PHENANTHRIDINE
  • Gazi University Affiliated: Yes

Abstract

© 2018 Elsevier B.V.An improved microwave-induced synthesis of five ethidium derivatives (Ethidium derivatives, 2a–d) is presented. As the derivatives 2a–d have been proposed previously to be telomerase inhibitors, the binding interactions of these ethidium derivatives with G-quadruplex DNA were evaluated by means of photometric and fluorimetric titration, thermal DNA denaturation, CD and 1H NMR spectroscopy. In particular, the compound bearing 3,8-bis(pyrrolidin-1-yl)propanamido substituent 2a exhibits high selectivity for G-quadruplex DNA relative to duplex DNA.