Peroxisome proliferators-activated alpha agonist treatment ameliorates hepatic damage in rats with obstructive jaundice: an experimental study


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CİNDORUK M., KEREM M., KARAKAN T., Salman B., Akin O., Alper M., ...More

BMC GASTROENTEROLOGY, vol.7, 2007 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 7
  • Publication Date: 2007
  • Doi Number: 10.1186/1471-230x-7-44
  • Journal Name: BMC GASTROENTEROLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus

Abstract

Background: Peroxisome proliferators-activated receptor alpha ( PPAR alpha) activation modulates cholesterol metabolism and suppresses bile acid synthesis. This study aims to evaluate the effect of short-term administration of fenofibrate, a PPAR alpha agonist, on proinflammatory cytokines, apoptosis, and hepatocellular damage in cholestasis.