Elimination of O-center dot(2)-/H2O2 by alpha-lipoic acid mediates the recovery of basal EDRF/NO availability and the reversal of superoxide dismutase-induced relaxation in diabetic rat aorta


Kocak G., Karasu Ç.

DIABETES OBESITY & METABOLISM, vol.4, no.1, pp.69-74, 2002 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 4 Issue: 1
  • Publication Date: 2002
  • Doi Number: 10.1046/j.1463-1326.2002.00174.x
  • Title of Journal : DIABETES OBESITY & METABOLISM
  • Page Numbers: pp.69-74
  • Keywords: superoxide dismutase, rat aorta, streptozotocin-diabetes, nitric oxide, alpha-lipoic acid, hydrogen peroxide, endothelium, ENDOTHELIUM-DEPENDENT RELAXATION, VASCULAR REACTIVITY, ENERGY-METABOLISM, INSULIN-TREATMENT, VITAMIN-E, ANTIOXIDANT, DYSFUNCTION, CELLS

Abstract

Aim: The aims of this study were to ascertain the mechanism(s) of relaxant action of exogenous superoxide dismutase (SOD) in aortic rings obtained from 12-week, streptozotocin (STZ)-diabetic and age-matched control rats, and to examine the effects of a-lipoic acid (ALA) treatment (for 6 weeks, after 6 weeks of untreated diabetes) on SOD-induced relaxations.