DIABETES OBESITY & METABOLISM, vol.4, no.1, pp.69-74, 2002 (Journal Indexed in SCI)
Article / Article
Title of Journal :
DIABETES OBESITY & METABOLISM
superoxide dismutase, rat aorta, streptozotocin-diabetes, nitric oxide, alpha-lipoic acid, hydrogen peroxide, endothelium, ENDOTHELIUM-DEPENDENT RELAXATION, VASCULAR REACTIVITY, ENERGY-METABOLISM, INSULIN-TREATMENT, VITAMIN-E, ANTIOXIDANT, DYSFUNCTION, CELLS
Aim: The aims of this study were to ascertain the mechanism(s) of relaxant action of exogenous superoxide dismutase (SOD) in aortic rings obtained from 12-week, streptozotocin (STZ)-diabetic and age-matched control rats, and to examine the effects of a-lipoic acid (ALA) treatment (for 6 weeks, after 6 weeks of untreated diabetes) on SOD-induced relaxations.