Neuroprotective effects of adrenomedullin in experimental traumatic brain injury model in rats

EMMEZ G., Bulduk E. B., Yildirim Z.

ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY, vol.28, no.6, pp.736-742, 2022 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 6
  • Publication Date: 2022
  • Doi Number: 10.14744/tjtes.2021.01954
  • Journal Name: ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.736-742
  • Keywords: Adrenomedullin, inflammation, oxidative stress, traumatic brain injury, CLOSED-HEAD INJURY, SPINAL-CORD-INJURY, ISCHEMIA, COMBINATION, DEFICIENCY, PEPTIDE, SYSTEM
  • Gazi University Affiliated: Yes

Abstract

BACKGROUND: Traumatic brain injuries cause damages in the brain in several ways, which include cell death because of edema, disruption of the blood-brain barrier, shear stress, and ischemia. In this study, we investigated the effects of adrenomedullin (AM) on oxidative stress and inflammation after head traumas in a rat model.