VASCULAR PHARMACOLOGY, vol.113, pp.38-46, 2019 (Journal Indexed in SCI)
Article / Article
Title of Journal :
Hypertension, Endoplasmic reticulum stress, Vascular dysfunction, TUDCA, GROWTH-FACTOR RECEPTOR, SMOOTH-MUSCLE-CELLS, ENDOTHELIAL DYSFUNCTION, OXIDATIVE STRESS, ANTIOXIDANT STATUS, TYROSINE KINASE, CARDIAC DAMAGE, BLOOD-PRESSURE, ER STRESS, RESISTANCE
Hypertension has complex vascular pathogenesis and therefore the molecular etiology remains poorly elucidated. Endoplasmic reticulum stress (ERS), which is a condition of the unfolded/misfolded protein accumulation in the endoplasmic reticulum, has been defined as a potential target for cardiovascular disease. In the present study, the effects of ERS inhibition on hypertension-induced alterations in the vessels were investigated.