Aortic cross-clamping-induced spinal cord oxidative stress in rabbits: The role of a novel antioxidant adrenomedullin

Oyar E. O., Korkmaz A., Kardes O., ÖMEROĞLU S.

JOURNAL OF SURGICAL RESEARCH, vol.147, no.1, pp.143-147, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 147 Issue: 1
  • Publication Date: 2008
  • Doi Number: 10.1016/j.jss.2007.06.025
  • Journal Name: JOURNAL OF SURGICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.143-147
  • Keywords: adrenomedullin, ischemia-reperfusion, oxidative stress, spinal cord, ISCHEMIA/REPERFUSION INJURY, GLUTATHIONE
  • Gazi University Affiliated: Yes

Abstract

Background. Spinal cord injury remains a devastating complication of thoracic and thoracoabdominal aortic operations. We aim to investigate the neuroprotective role of adrenomedullin (AM) administered to rabbits before ischemia and during reperfusion against ischemia-reperfusion (I/R) injury.