Comparison of Melatonin Effect on Oxidant Status and Antioxidant Capacity in Liver and Heart of Young and Aged Rats


GÜNEY Ş. , Cumaoglu A., ÖZTÜRK G., AKBULUT K. G. , KARASU Ç.

INTERNATIONAL JOURNAL OF GERONTOLOGY, vol.7, no.1, pp.45-49, 2013 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.1016/j.ijge.2012.11.010
  • Title of Journal : INTERNATIONAL JOURNAL OF GERONTOLOGY
  • Page Numbers: pp.45-49
  • Keywords: aging, antioxidant, melatonin, oxidant, SUPEROXIDE-DISMUTASE ACTIVITY, OXIDATIVE DAMAGE, CALORIC RESTRICTION, LIPID-PEROXIDATION, HYDROGEN-PEROXIDE, GENE-EXPRESSION, PINEAL CONTROL, STRESS, ENZYMES, MITOCHONDRIA

Abstract

Background: Oxidative stress is involved in several pathologic conditions such as metabolic or cardiovascular disease, and in aging. Oxidative damage of biomolecules increases with age. Melatonin is the main neurohormone of the pineal gland and specific antioxidants may act against age-related oxidative damage.