Nitroglycerin challenge induces lateralized headache in nasociliary nerve-ligated rats: implications for chronic migraine


Akcali D. T., Belen A. D., Babacan A., Bolay H. B.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.47, no.2, pp.681-688, 2017 (SCI-Expanded, Scopus, TRDizin)

  • Publication Type: Article / Article
  • Volume: 47 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.3906/sag-1602-86
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.681-688
  • Keywords: Rat, nitroglycerin, chronic migraine, headache, nasociliary nerve ligation, c-fos, ELEVATED PLUS-MAZE, VON FREY MONOFILAMENTS, TRIGEMINAL NEURONS, FACIAL STIMULATION, MODEL, ALLODYNIA, RESPONSES, PAIN, ANXIETY, INJURY
  • Gazi University Affiliated: Yes

Abstract

Background/aim: Chronic migraine is a common debilitating disease with limited treatment options. We aimed to develop a novel model for chronic migraine by ligating the nasociliary nerve (NCL) and administering nitroglycerin (NTG) to exacerbate acute headache attacks.