The effects of indomethacin, NDGA, allopurinol and superoxide dismutase on prostaglandin E(2) and leukotriene C-4 levels after mesenteric ischemia-reperfusion injury

Sare M., Bozkurt S., Onuk E., Oguz M., Gurel M., Ercan S.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, vol.55, no.6, pp.379-383, 1996 (SCI-Expanded) identifier identifier identifier


In this study, the changes of arachidonic acid metabolites after an ischemia-reperfusion (I/R) period are investigated. The cyclooxygenase and lipoxygenase metabolites were found to be significantly increased after a 45 min period of ischemia followed by 5 min of reperfusion. Prostaglandin E(2) (PGE(2))- and leukotriene C-4 (LTC(4))-like activities did not change in the ischemic period, but they both increased after reperfusion. A cyclooxygenase inhibitor indomethacin and lipoxygenase inhibitor nordehydroguaretic acid (NDGA) decreased PGE(2)- and LTC(4)-like activities, respectively, while allopurinol and superoxide dismutase (SOD) decreased both activities.