Thiopurine methyltransferase polymorphisms and mercaptopurine tolerance in Turkish children with acute lymphoblastic leukemia.

Albayrak, Meryem; Konyssova, Uljan; Kaya, ZÜHRE; Gursel, Turkiz; Guntekin, Sezen; Perçin, FERDA; Kocak, Ulker

doi:10.1007/s00280-011-1599-7

Thiopurine methyltransferase polymorphisms and mercaptopurine tolerance in Turkish children with acute lymphoblastic leukemia.

Albayrak M., Konyssova U., Kaya Z., Gursel T., Guntekin S., Perçin F. E., ...Daha Fazla

Cancer chemotherapy and pharmacology, cilt.68, sa.5, ss.1155-9, 2011 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 68 Sayı: 5
Basım Tarihi: 2011
Doi Numarası: 10.1007/s00280-011-1599-7
Dergi Adı: Cancer chemotherapy and pharmacology
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1155-9
Anahtar Kelimeler: Thiopurine methyltransferase polymorphisms, Mercaptopurine, Children, Leukemia, S-METHYLTRANSFERASE, GENETIC POLYMORPHISMS, CAUCASIAN POPULATION, TPMT GENOTYPE, ALLELES, AZATHIOPRINE, THERAPY, PHARMACOGENETICS, INTOLERANCE
Gazi Üniversitesi Adresli: Evet

Özet

Thiopurine methyltransferase (TPMT) enzyme is involved in the metabolism of 6-mercaptopurine (6-MP), a key component of acute lymphoblastic leukemia (ALL) treatment protocols in children. The aims of this study were to investigate the frequency of common genetic polymorphisms associated with low TPMT activity and correlations of polymorphic variants with 6-MP tolerance in a group of Turkish children with ALL.