Influence of Folate-Related Gene Polymorphisms on High-Dose Methotrexate-Related Toxicity and Prognosis in Turkish Children with Acute Lymphoblastic Leukemia

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Yazıcıoğlu B., Kaya Z., Ergun S. G., Percin F. E., Koçak Ü., Yenicesu I., ...Daha Fazla

TURKISH JOURNAL OF HEMATOLOGY, cilt.34, sa.2, ss.143-150, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.4274/tjh.2016.0007
  • Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.143-150
  • Anahtar Kelimeler: Methotrexate, Toxicity, Prognosis, Folate-related gene polymorphisms, THYMIDYLATE SYNTHASE GENE, METHYLENETETRAHYDROFOLATE REDUCTASE C677T, THERAPY, MTHFR, PHARMACOGENETICS, ASSOCIATION, SURVIVAL, PATHWAY, RISK, METAANALYSIS
  • Gazi Üniversitesi Adresli: Evet

Özet

Objective: High-dose methotrexate (HD-MTX) is widely used in the consolidation phase of childhood acute lymphoblastic leukemia (ALL), but the roles that polymorphisms in folate-related genes (FRGs) play in HD-MTX toxicity and prognosis in children with ALL are not understood. The aims of this study were to investigate the frequencies of polymorphisms in the genes for thymidylate synthase (TS), methionine synthase reductase (MTRR), and methylene tetrahydrofolate reductase (MTHFR) in Turkish children with ALL and to assess associations between these polymorphisms and HD-MTX-related toxicity and leukemia prognosis in this patient group.