Possible Anti-Obesity Role of Flavonoids Through Brown Adipose Tissue
CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, cilt.14, sa.1, ss.253-263, 2024 (ESCI, TRDizin)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 14 Sayı: 1
- Basım Tarihi: 2024
- Doi Numarası: 10.33808/clinexphealthsci.1082047
- Dergi Adı: CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.253-263
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Gazi Üniversitesi Adresli: Evet
Özet
Worldwide, the incidence of overweight and obesity is increasing day by day, and this makes the control of body weight and complications a primary health problem. Weight loss diet therapy has long been a primary role in the prevention and management of obesity. Evidence supporting the specific anti-obesity effects of certain nutrient components, in particular, polyphenolic compounds, are increasing, as well as a strategy to limit energy intake to achieve control of body weight. Active brown adipose tissue in adult individuals is gaining interest as a new and feasible target for controlling body weight by triggering and increasing energy expenditure. Flavonoids are one of the polyphenolic compounds that draw attention by regulating non-shivering thermogenesis. Although each flavonoid has its health benefits; many phytochemical compounds classified as flavonoids have an anti-obesity effect by regulating oxidation, synthesis, uptake, and transport of fatty acids. In this study, current studies on the therapeutic effect of flavonoids on obesity by regulating energy expenditure through various mechanisms of action in brown adipose tissue are reviewed.