In Vitro Cytotoxic Activities of Platinum(II) Complex with 1-Methyl-2-(3 '-hydroxypropyl)benzimidazole and 2-(3 '-Hydroxypropyl)benzimidazolium Hexa- and Tetrachloroplatinate Salts

EREN G., Yilmaz S., Gumus F.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.15, no.1, pp.65-69, 2018 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.2174/1570180814666171012163325
  • Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.65-69
  • Keywords: Platinum complex, benzimidazole, cytotoxic activity, in vitro, DNA, RNA, SUBSTITUTED BENZIMIDAZOLE LIGANDS, DNA INTERACTIONS, BINDING, DRUGS, 2-HYDROXYMETHYLBENZIMIDAZOLE, THERAPEUTICS, CISPLATIN, CHEMISTRY, AGENTS, MCF-7
  • Gazi University Affiliated: Yes

Abstract

Background: Platinum complexes as antitumor agents have received considerable attention due to the clinically approved and have been marketed worldwide such as cisplatin, carboplatin, oxaliplatin or marketed locally such as nedaplatin, lobaplatin and heptaplatin for treatment of various tumor diseases. However, those drugs still had their own defects and they exhibited side effects including nephrotoxicity, ototoxicity, neurotoxicity and bone marrow suppression. Therefore there is still continuing interest in the development of new platinum drugs avoiding their inherent resistance and toxicity.