Biomonitoring cytogenetic and oxidative-stress related damage in gas station attendants: Buccal micronucleus cytome assay and serum 8-OHdG levels
Archives of Environmental and Occupational Health, cilt.80, sa.7-8, ss.165-173, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 80 Sayı: 7-8
- Basım Tarihi: 2025
- Doi Numarası: 10.1080/19338244.2025.2520850
- Dergi Adı: Archives of Environmental and Occupational Health
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Agricultural & Environmental Science Database, BIOSIS, CAB Abstracts, EMBASE, Environment Index, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.165-173
- Anahtar Kelimeler: Benzene, DNA damage, gasoline, occupational hazards, oxidative stress
- Gazi Üniversitesi Adresli: Evet
Özet
This study assessed the genotoxicity and oxidative DNA damage associated with occupational exposure among gas station attendants. We performed buccal micronucleus cytome analysis and measured serum 8-OHdG levels in 32 pumpers and 32 control subjects. Cytotoxicity biomarkers were higher in the exposed group. No significant effect of smoking on cytogenetic parameters was found. In contrast, a higher frequency of genotoxicity and cytotoxicity biomarkers was observed in pumpers with more than 10 years of employment. Serum 8-OHdG levels were higher in pumpers. While the duration of working increased the serum 8-OHdG levels, smoking had no significant effect. Our findings reveal that gas station attendants are continuously exposed to benzene-induced toxicity at the cellular level. Workers may be at risk of developing cancer in the future, so they should be carefully monitored for the long-term effects.