Lead nitrate and cadmium chloride induced hepatotoxicity and nephrotoxicity: Protective effects of sesamol on biochemical indices and pathological changes

Bas H., Apaydın F. G., Kalender S., Kalender Y.

JOURNAL OF FOOD BIOCHEMISTRY, vol.45, no.7, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 7
  • Publication Date: 2021
  • Doi Number: 10.1111/jfbc.13769
  • Journal Name: JOURNAL OF FOOD BIOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts, Business Source Elite, Business Source Premier, CAB Abstracts, Compendex, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Keywords: cadmium, heavy metal, kidney, lead, liver, sesamol, INDUCED OXIDATIVE STRESS, LIPID-PEROXIDATION, SODIUM SELENITE, DNA-DAMAGE, LIVER, ANTIOXIDANT, KIDNEY, TOXICITY, EXPOSURE, RATS
  • Gazi University Affiliated: Yes

Abstract

Lead nitrate (LN) and cadmium chloride (CdCl2), regarded as environmental contaminants, are toxic heavy metals. Sesamol is a dietary phytochemical found in sesame oil. We aimed to analyze the hepatotoxic and nephrotoxic effects of LN and CdCl2 and to evaluate the possible protective effect of sesamol. LN (90 mg/kg bw per day), CdCl2 (3 mg/kg bw per day), and sesamol (50 mg/kg bw per day) were given to rats via gavage for 28 days. Total protein, albumin, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, total cholesterol, urea, uric acid, creatinine, superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, malondialdehyde, acetylcholinesterase, and histopathological changes were investigated in liver and kidney tissues. Lead and cadmium were found to result in decreases in the antioxidant enzymes and acetylcholinesterase activities, increases in malondialdehyde levels, and changes in serum biochemical parameters and various pathological findings. An improvement in all these parameters was observed in the sesamol-treated groups.