Synthesis, characterization, and pharmacological evaluation of the proton transfer salts of 2-aminobenzothiazole derivatives with 5-sulfosalicylic acid and their Cu(II) complexes

İLKİMEN H., TEKŞEN Y., YENİKAYA C., Turhan I., TUNÇ T., SARI M.

JOURNAL OF COORDINATION CHEMISTRY, cilt.71, ss.2831-2842, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 71
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1080/00958972.2018.1504035
  • Dergi Adı: JOURNAL OF COORDINATION CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2831-2842
  • Anahtar Kelimeler: 2-Aminobenzothiazole derivatives, 5-sulfosalicylic acid, proton transfer salt, anti-inflammatory activity, analgesic activity, 2,6-PYRIDINEDICARBOXYLIC ACID, COPPER(II) COMPLEXES, INHIBITION, DIVERSITY
  • Gazi Üniversitesi Adresli: Evet

Özet

Two proton transfer compounds, formed between 2-aminobenzothiazole derivatives (2-aminobenzothiazole (abt) and 2-amino-6-ethoxybenzothiazole (EtOabt)) and 5-sulfosalicylic acid dihydrate (H3ssa) as parent compounds, (Habt)(+) (H2ssa)(-) (1) and (HEtOabt)(+) (H2ssa)(-) (2) and their Cu(II) complexes (3 and 4, respectively) have been prepared and characterized using spectroscopic techniques. The single crystal X-ray diffraction method has been also applied to 3 and 4. Although 3 has a distorted octahedral form, 4 exhibits a distorted square pyramidal geometry. All compounds, including saline and diclofenac sodium as standards, have been evaluated pharmacologically for their anti-inflammatory and analgesic activities in rats and mice. Parent compounds (abt, EtOabt, and H3ssa) 3 and 4 showsignificant anti-inflammatory and analgesic activities as compared with control compounds.