Synthesis and antinociceptive activity of 6-substituted-3-pyridazinone derivatives

Gokce M., DOĞRUER D. S., Sahin M.

FARMACO, cilt.56, sa.3, ss.233-237, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 56 Sayı: 3
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1016/s0014-827x(01)01037-0
  • Dergi Adı: FARMACO
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.233-237
  • Anahtar Kelimeler: 6-substituted-3-pyridazinone derivatives, antinociceptive activity, Koster test, AGENTS, CARDIOTONICS
  • Gazi Üniversitesi Adresli: Evet

Özet

A series of 3-pyridazinones carrying morpholino, arylpiperidino and arylpiperazino moiety in the position 6 IIa-g were synthesized and evaluated for antinociceptive activity. In the modified Koster test in mice 4-(4-fluorophenyl) piperazine, IIf, was found the most active compound. All the compounds except IId were more active than aspirin in the antinociceptive activity test. (C) 2001 Elsevier Science S.A. All rights reserved.