Dexmedetomidine protects from post-myocardial ischaemia reperfusion lung damage in diabetic rats

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KİP G., ÇELİK A., Bilge M., ALKAN M., KİRAZ H. A., ÖZER A., ...Daha Fazla

LIBYAN JOURNAL OF MEDICINE, cilt.10, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3402/ljm.v10.27828
  • Dergi Adı: LIBYAN JOURNAL OF MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Diabetes Mellitus, dexmedetomidine, ischaemia reperfusion, lung, ISCHEMIA/REPERFUSION INJURY, FREE-RADICALS, LEVOSIMENDAN, EXPRESSION, LIVER, MICE
  • Gazi Üniversitesi Adresli: Evet

Özet

Objective: Diabetic complications and lipid peroxidation are known to have a close association. Lipid peroxidation commonly occurs at sites exposed to ischaemia, but distant organs and tissues also get damaged during ischaemia/reperfusion (I/R). Some of these targets are vital organs, such as the lung, liver, and kidney; the lung is the most frequently affected. The aim of our study was to investigate the effects of dexmedetomidine on I/R damage in lung tissue and on the oxidant/anti-oxidant system in diabetic rats.