Comparative study of receptor discordance between primary and corresponding metastatic lesions in breast cancer

Erdem G. U., Altundag K., Ozdemir N. Y., Sahin S., Demirci N. S., Karatas F., ...Daha Fazla

JOURNAL OF BUON, cilt.22, sa.2, ss.365-376, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 2
  • Basım Tarihi: 2017
  • Dergi Adı: JOURNAL OF BUON
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.365-376
  • Anahtar Kelimeler: breast cancer, discordance, HER-2, hormone receptor, metastatic, primary, PROGESTERONE-RECEPTOR, ESTROGEN-RECEPTOR, HER-2 STATUS, HORMONE-RECEPTOR, MONOCLONAL-ANTIBODY, PROGNOSTIC IMPACT, LOCALLY RECURRENT, EXPRESSION, RESISTANCE, SITES
  • Gazi Üniversitesi Adresli: Evet

Özet

Purpose: It is well-known that tumor phenotype may change during the progression of breast cancer (BC). The purpose in this study was to compare the discordance in estrogen receptor (ER), progesterone receptor (PgR) and human epidermal growth factor receptor 2 (HER2) between primary and recurrent/metastatic lesions (RML) and also to evaluate the prognostic significance of change in tumor phenotype on survival in patients with metastatic BC.