Assessment of expressions of Bcl-XL, b-FGF, Bmp-2, Caspase-3, PDGFR-alpha, Smad1 and TGF-beta 1 genes in a rat model of lung ischemia/reperfusion

Simsek H., DEMİRYÜREK Ş., DEMİR T., Atabay H. D., ÇERİBAŞI A. O., Bayraktar R., ...Daha Fazla

IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, cilt.19, sa.2, ss.209-214, 2016 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 2
  • Basım Tarihi: 2016
  • Dergi Adı: IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.209-214
  • Anahtar Kelimeler: Apoptosis, Growth factors, Ischemia/reperfusion, Lung, ISCHEMIA-REPERFUSION INJURY, BONE MORPHOGENETIC PROTEIN-2, EMERGING ROLES, TGF-BETA, APOPTOSIS, PATHWAY, GROWTH
  • Gazi Üniversitesi Adresli: Evet

Özet

Objective(s): Ischemia is described as organs and tissues are destitute of oxygen due to decreased arterial or venous blood flow. Many mechanisms play role in cell death happened as a consequence of a new blood flow is needed for both cell regeneration and to clean toxic metabolites during ischemia and later. Lung damage induced by ischemia/reperfusion (I/R) is a frequent problem in lung transplantation. Apoptosis (programmed cell death) is known as cell suicide, and plays a key role in embryonic developmental and in maintain adult tissue's life.