Prognostic significance of standardised uptake value (SUVmax) measured on 18F-fluorodeoxyglucose positron emission tomography/computed tomography in patients with small cell lung cancer

Demirci N., Yilmaz U., Uslu I. B., Dikmen A., Yilmaz A., Erdogan Y.

EUROPEAN JOURNAL OF CANCER CARE, cilt.26, sa.5, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 5
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1111/ecc.12485
  • Dergi Adı: EUROPEAN JOURNAL OF CANCER CARE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Anahtar Kelimeler: F-18-fluorodeoxyglucose positron emission tomography/computed tomography, maximum standardised uptake value (SUVmax), prognosis, small cell lung cancer, PROGRESSION-FREE SURVIVAL, STAGING PROJECT, 7TH EDITION, FDG-PET, TUMOR, FLUORODEOXYGLUCOSE, CLASSIFICATION, RADIOTHERAPY, METAANALYSIS, PROPOSALS
  • Gazi Üniversitesi Adresli: Evet

Özet

Certain prognostic factors for small cell lung cancer (SCLC) have been validated, but the prognostic role of 18F-FDG PET/CT still remains unclear. The aim of this study was to evaluate the prognostic significance of 18F-FDG PET/CT in patients with SCLC. We reviewed 142 patients with pathologically proven SCLC who underwent pre-treatment 18F-FDG PET/CT. Standardised uptake value (SUVmax) and other potential prognostic variables were chosen for analysis. The mean age of the study population was 58.2 +/- 10.1 years (range, 25-84), and 124 (87.3%) patients were men. The median SUVmax value was 11.6 (4.0-29.3). Among the variables included in the univariate analysis, performance status (P = 0.001), disease stage (P < 0.001), administration of thoracic radiotherapy (TRT; P < 0.001), albumin level (P = 0.030) and LDH level (P < 0.001) showed prognostic significance. Further, multivariate analysis showed that performance status (P = 0.007), albumin level (P = 0.002), LDH level (P < 0.001) and administration of TRT (P = 0.001) were independent prognostic factors for survival. In conclusion, performance status, TRT, LDH level and albumin level were identified as important prognostic factors, while 18F-FDG PET/CT uptake of the primary lesions did not have any prognostic significance for survival in patients with SCLC.