Protective role of antioxidant vitamins on adriamycin-induced free radical production and cardiotoxicity in guinea pigs

Durak I., Ozturk H., Kavutcu M., Birey M., Yel M., Guven T., ...More

CANCER RESEARCH THERAPY & CONTROL, vol.5, no.2, pp.133-141, 1998 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 5 Issue: 2
  • Publication Date: 1998
  • Journal Name: CANCER RESEARCH THERAPY & CONTROL
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.133-141
  • Gazi University Affiliated: Yes

Abstract

Guinea pigs were divided into three groups: control, adriamycin and adriamycin plus vitamin groups, and treated with physiological saline solution (control group), adriamycin (adriamycin group) and adriamycin plus vitamins E and C (adriamycin plus vitamin group). Activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) and concentrations of malondialdehyde (MDA), conjugated dienes (CD), hydroxyl radical (OH.) and iron were measured in heart and liver tissues of all animals. Electron microscopic analysis and free radical concentrations of all tissues were also carried out.