Methomyl-induced nephrotoxicity and protective effect of curcumin in male rats

ASLANTÜRK A., KALENDER Y.

TOXICOLOGY RESEARCH, cilt.10, sa.5, ss.1003-1012, 2021 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 5
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1093/toxres/tfab080
  • Dergi Adı: TOXICOLOGY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aqualine, BIOSIS, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, Pollution Abstracts
  • Sayfa Sayıları: ss.1003-1012
  • Anahtar Kelimeler: curcumin, kidney, light microscopy, methomyl, oxidative stress, OXIDATIVE STRESS, ANTIOXIDANT STATUS, VITAMINS C, ACID, DAMAGE, INSECTICIDE, TOXICITY, MIXTURE, HEPATOTOXICITY, DIAZINON
  • Gazi Üniversitesi Adresli: Evet

Özet

We investigated the ameliorative effect of the curcumin against methomyl-induced potential nephrotoxicity in Wistar albino male rats. In the present study, curcumin (100 mg kg(-1) bw), methomyl (0,8 mg kg(-1) bw) and methomyl plus curcumin were given to rats by oral for 28 days (for subacute examination). Concentrations of blood urea nitrogen, uric acid and creatinine in serum and malondialdehyde level and activities of antioxidant enzyme (superoxide dismutase, catalase, glutathione peroxidase and glutathione S transferase) and histopathological alterations in kidney tissues were studied. Methomyl caused an increment in the concentrations of blood urea nitrogen, creatinine, uric acid and MDA levels. In addition, methomyl caused a diminution in the activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione S transferase. Tubular and glomerular degenerations occurred in the kidney tissues of methomyl-received rats. However, coadministration of curcumin with methomyl significantly minimized the adverse effects of methomyl on kidney function parameters, lipid peroxidation and antioxidant enzyme activities and histological structure of kidney tissue. The results showed that curcumin significantly mitigated methomyl-induced nephrotoxicity in rats.