Evaluation of serum procollagen C-proteinase enhancer 1 level as a fibrosis marker in patients with chronic hepatitis B


Gokce O., Ozenirler S., Yucel A. A. , Oruklu N. , ESENDAĞLI G. , KARAHAN S.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, vol.30, no.8, pp.918-924, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 8
  • Publication Date: 2018
  • Doi Number: 10.1097/meg.0000000000001123
  • Title of Journal : EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
  • Page Numbers: pp.918-924
  • Keywords: chronic hepatitis B, liver biopsy, liver fibrosis, noninvasive marker, procollagen C-proteinase enhancer 1, CHRONIC VIRAL-HEPATITIS, LIVER FIBROSIS, VIRUS INFECTION, DISEASE, BIOPSY, PCPE-1, FIBROGENESIS, FIBROBLASTS, CIRRHOSIS, PROTEOME

Abstract

Aim Although liver biopsy has long been considered the gold standard for staging fibrosis, because of the disadvantages and risks of biopsy, several noninvasive processes such as serum biomarkers have been introduced for the assessment of liver fibrosis. The aim of this study was to assess the diagnostic value of serum procollagen C-proteinase enhancer 1 (PCPE-1) as a noninvasive fibrosis marker in treatment-naive chronic hepatitis B patients.