N-(2-Pyridinyl)-2-[2(3H)-benzazolone-3-YL]acetamides: Synthesis, antinociceptive and anti-inflammatory activity

DOĞRUER D. S., Unlu S., Yesilada E., Sahin M.

FARMACO, cilt.52, sa.12, ss.745-750, 1997 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 52 Sayı: 12
  • Basım Tarihi: 1997
  • Dergi Adı: FARMACO
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.745-750
  • Gazi Üniversitesi Adresli: Evet

Özet

Eighteen N-(2-Pyridyl)-2-[2(3H)-benzazolone-3-yl]acetamide derivatives have been synthesized. The chemical structure of the compounds have been elucidated by elemental analysis. IR and H-1 NMR spectral data and their antinociceptive and anti-inflammatory activities were tested in mice. Compound VII o has shown the highest antinociceptive activity, and Vn g,j, k, r exhibited relatively high antinociceptive activity. In addition, compounds VII d, f,j, p showed statistically significant anti-inflammatory activity.