Effect of nordihydroguaretic acid and fluconazole on the LTC4/PGE(2) ratio in the kidney of mice damaged by Candida albicans

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Atıf İçin Kopyala

Kustimur S., Memis L., Kilinc M., Ercan Z.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, cilt.56, sa.4, ss.281-283, 1997 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 56 Sayı: 4
• Basım Tarihi: 1997
• Doi Numarası: 10.1016/s0952-3278(97)90571-8
• Dergi Adı: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.281-283
• Gazi Üniversitesi Adresli: Hayır

Özet

The kidney is a major target organ in generalized candidiasis. When mice were infected with C. albicans, prostaglandin E-2 (PGE(2))-like activity was found to be significantly decreased while leukotriene C-4 (LTC4)-like activity increased in the kidneys within 10 days. The aim of this study is to investigate the effect of nordihydroguaretic (NDGA) and fluconazole on the LTC4/PGE(2) ratio in the mice kidneys infected by proteinase (+) C. albicans. The LTC4/PGE(2) ratio was found to be significantly decreased both in NDGA and fluconazole-pretreated groups. These results indicate that pretreatment with the lipoxygenase inhibitor NDGA and the antifungal drug fluconazole, protect the kidney against C. albicans infection. These results also indicate a possible role of arachidonic acid metabolites (increase LTC4 and decrease PGE(2)) in kidney damage due to C. albicans infection.