Ursodeoxycholic acid in intrahepatic cholestasis of pregnancy: a systematic review and individual participant data meta-analysis


Ovadia C., Sajous J., Seed P. T., Patel K., Williamson N. J., Attilakos G., ...Daha Fazla

LANCET GASTROENTEROLOGY & HEPATOLOGY, cilt.6, sa.7, 2021 (SCI-Expanded) identifier identifier identifier identifier

Özet

Background Ursodeoxycholic acid is commonly used to treat intrahepatic cholestasis of pregnancy, yet its largest trial detected minimal benefit for a composite outcome (stillbirth, preterm birth, and neonatal unit admission). We aimed to examine whether ursodeoxycholic acid affects specific adverse perinatal outcomes.