Synthesis of Some New 3(2H)-Pyridazinone Derivatives and Evaluation of their Analgesic-anti-inflammatory and Antimicrobial Activities

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Sukuroglu M. K., Yamali C., Tiryaki D., Onurdag F. K., AKKOL E., DOĞRUER D. S.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.10, no.6, pp.507-514, 2013 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 10 Issue: 6
• Publication Date: 2013
• Doi Number: 10.2174/1570180811310060006
• Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.507-514
• Gazi University Affiliated: Yes

Abstract

In this study, 15 new 3(2H)-pyridazinone derivatives carrying N'-(4-substitutedphenylmethylidene)acetohydrazide moiety on lactam nitrogen were synthesized and their chemical structures were confirmed by H-1-NMR, mass, and elemental analysis. Analgesic and anti-inflammatory activities of the synthesized compounds were evaluated in mice. Among the synthesized compounds, compound 11e exhibited the best analgesic and anti-inflammatory activities, without causing any gastric effect in stomachs of tested animals. Additionally, the synthesized compounds were screened for their antibacterial and antifungal activities against some pathogenic strains.