Resequencing Study Confirms That Host Defense and Cell Senescence Gene Variants Contribute to the Risk of Idiopathic Pulmonary Fibrosis

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Moore C., Blumhagent R. Z., Yang I., Walts A., Powers J., Walker T., ...Daha Fazla

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, cilt.200, sa.2, ss.199-208, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 200 Sayı: 2
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1164/rccm.201810-1891oc
  • Dergi Adı: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.199-208
  • Anahtar Kelimeler: targeted resequencing, idiopathic pulmonary fibrosis, genetic variants, rare variants, disease risk alleles, MUC5B PROMOTER POLYMORPHISM, GENOME, SUSCEPTIBILITY, MUTATIONS, ASSOCIATION, EXPRESSION, DISEASE, LOCI
  • Gazi Üniversitesi Adresli: Evet

Özet

Rationale: Several common and rare genetic variants have been associated with idiopathic pulmonary fibrosis, a progressive fibrotic condition that is localized to the lung.